Journal article

Effects of saline or albumin resuscitation on standard coagulation tests

Rinaldo Bellomo, Hiroshi Morimatsu, Jeff Presneill, Craig French, Louise Cole, David Story, Shigehiko Uchino, Toshio Naka, Simon Finfer, D James Cooper, John Myburgh

CRITICAL CARE AND RESUSCITATION | AUSTRALASIAN MED PUBL CO LTD | Published : 2009

Abstract

AIMS: To explore whether fluid resuscitation with normal saline or 4% albumin is associated with differential changes in routine clinical coagulation tests. DESIGN: Substudy from a large double-blind randomised controlled trial, the SAFE (Saline versus Albumin Fluid Evaluation) study. SETTING: Three general intensive care units. PATIENTS: Cohort of 687 critically ill patients. INTERVENTION: We randomly allocated patients to receive either 4% human albumin or normal saline for fluid resuscitation, and collected demographic and haematological data. METHODS AND MAIN RESULTS: Albumin was administered to 338 patients and saline to 349. At baseline, the two groups had similar mean activated partia..

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Grants

Funding Acknowledgements

This study was supported by the Australian Government Department of Health and Ageing, CSL Bioplasma (Melbourne, Victoria), the Australian National Health and Medical Research Council, Health Department of Western Australia, New South Wales Health Department, Northern Territory Health Services, Queensland Health Services Department, Royal Hobart Hospital (Tasmania), South Australian Department of Human Services, Victorian Department of Human Services, Auckland District Health Board, Middlemore Hospital, and Health Research Council of New Zealand.