Journal article

Diagnostic specificity of the insular cortex abnormalities in first-episode psychotic disorders

Tsutomu Takahashi, Stephen J Wood, Bridget Soulsby, Ryoichiro Tanino, Michael TH Wong, Patrick D McGorry, Michio Suzuki, Dennis Velakoulis, Christos Pantelis

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2009

Abstract

Volume reductions of the insular cortex have been described in schizophrenia, but it remains unclear whether other psychotic disorders such as affective psychosis also exhibit insular cortex abnormalities. In this study, we used magnetic resonance imaging to investigate the gray matter volume of the anterior (short) and posterior (long) insular cortices in 162 first-episode patients with various psychotic disorders (46 schizophrenia, 57 schizophreniform disorder, 34 affective psychosis, and 25 other psychoses) and 62 age- and gender-matched healthy comparison subjects. Patients with schizophrenia showed bilateral volume reduction of the anterior and posterior insular cortices compared with c..

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Grants

Awarded by National Health & Medical Research Council (NHMRC)


Awarded by Japanese Society for the Promotion of Science


Awarded by Ministry of Health and Welfare (MS), Japan


Funding Acknowledgements

This study was supported by project grants from the National Health & Medical Research Council (NHMRC; grant IDS: 145627, 145737, 970598, 981112, 970391), NHMRC Program Grant (ID: 350241), and Colonial Foundation. DV and SJW were supported as Research Officers with funding from the NHMRC. PDM was supported by a NARSAD Distinguished Investigator Award. SJW is currently supported by a Clinical Career Development Award from the NHMRC (ID: 359223). TT was supported to undertake this work by a Grants-in-Aid for Scientific Research (No. 19591346) from the Japanese Society for the Promotion of Science (TT); and a Research Grant (17-2,18-6) for Nervous and Mental Disorders from the Ministry of Health and Welfare (MS), Japan. The authors are grateful to the clinical staff of the Early Psychosis Prevention and Intervention Centre (EPPIC) for their assistance in diagnostic and psychopathological assessments of the study participants.