Midline brain structures in patients with current and remitted major depression

T Takahashi; M Yücel; V Lorenzetti; K Nakamura; S Whittle; M Walterfang; M Suzuki; C Pantelis; NB Allen

Journal article

Midline brain structures in patients with current and remitted major depression

T Takahashi, M Yücel, V Lorenzetti, K Nakamura, S Whittle, M Walterfang, M Suzuki, C Pantelis, NB Allen

Progress in Neuro Psychopharmacology and Biological Psychiatry | Published : 2009

DOI: 10.1016/j.pnpbp.2009.05.020

Abstract

Brain morphologic changes of limbic-cortical regions have been reported in major depressive disorder (MDD). However, it remains largely unknown whether MDD is associated with abnormalities in midline brain structures, which play a critical role in limbic-cortical connectivity, and whether such changes reflect state or trait markers of the disorder. We used magnetic resonance imaging to investigate the length of the adhesio interthalamica (AI) and cavum septum pellucidum (CSP) in 29 currently depressed patients, 27 remitted depressed patients, and 33 age- and gender-matched healthy control subjects. The currently depressed patients had a significantly shorter AI compared with controls, but th..

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University of Melbourne Researchers

Sarah Whittle Author

Mark Walterfang Author

Christos Pantelis Author

Nick Allen Author

Related Projects (1)

INVESTIGATING THE SOCIAL BRAIN: THE NEURAL BASIS OF THE LINK BETWEEN DEPRESSED MOOD AND SOCIAL COGNITION

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This research was supported by a grant from the Australian Research Council (I.D. DP0557663) awarded to A/Prof. Allen and A/Prof Yucel. Neuroimaging analysis was facilitated by the Neuropsychiatry Imaging Laboratory managed by Ms. Bridget SouIsby at the Melbourne Neuropsychiatry Centre and supported by Neurosciences Victoria. The authors thank Ms. Orli Schwartz and Ms. Diana Maud for recruitment and assessment of the participants. A/Prof. Yucel is supported by an NHMRC Clinical Career Development Award (I.D. 509345). Ms. Lorenzetti is supported by a scholarship of the Faculty of Psychology, The University of Bologna, Italy. Dr. Walterfang was supported by a Pfizer Neuroscience Research Grant and a Stanley Research Centre Grant. Dr. Whittle was supported by an Australian Research Council Postdoctoral Fellowship. Dr. Takahashi was supported to undertake this work by a Grant-in-Aid for Scientific Research (No. 19591346) from the Japanese Society for the Promotion of Science; and a Research Grant (17-2,18-6) for Nervous and Mental Disorders from the Ministry of Health and Welfare (Dr. Suzuki), Japan. A/Prof. Allen is supported by a grant from the Colonial Foundation.