Journal article
Ttk69-dependent repression of lozenge prevents the ectopic development of R7 cells in the Drosophila larval eye disc
NA Siddall, GR Hime, JA Pollock, P Batterham
BMC Developmental Biology | BIOMED CENTRAL LTD | Published : 2009
Abstract
Abstract. Background. During the development of the Drosophila eye, specific cell types differentiate from an initially equipotent group of uncommitted precursor cells. The lozenge (lz) gene, which is a member of the Runt family of transcriptional regulators, plays a pivotal role in mediating this process through regulating the expression of several fate-specifying transcription factors. However, the regulation of lz, and the control of lz expression levels in different cell types is not fully understood. Results. Here, we show a genetic interaction between Tramtrack69 (Ttk69) a key transcriptional repressor and an inhibitor of neuronal fate specification, and lz, the master patterning gene ..
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Awarded by Australian Research Council
Funding Acknowledgements
We would like to thank Gregory Somers for critically reading this manuscript. We thank R. Saint, U. Banerjee, R. Stocker, Z.-C. Lai, M. Okabe, Y. Hiromi, B. Dickson and H. Richardson for reagents. This work was supported by an ARC Discovery Grant to Philip Batterham and grants to John Pollock from Duquesne University Faculty Development, NIH grant EY09093; NSF/STC grant BIR-8920118; Samuel and Emma Winters Foundation; The Duquesne University Hunkele Dreaded Disease Award and international collaborative support from the NSF INT-9605205.