Generating diversity: Mechanisms regulating the differentiation of autonomic neuron phenotypes
KN Cane, CR Anderson
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | ELSEVIER | Published : 2009
Sympathetic and parasympathetic postganglionic neurons innervate a wide range of target tissues. The subpopulation of neurons innervating each target tissue can express unique combinations of neurotransmitters, neuropeptides, ion channels and receptors, which together comprise the chemical phenotype of the neurons. The target-specific chemical phenotype shown by autonomic postganglionic neurons arises during development. In this review, we examine the different mechanisms that generate such a diversity of neuronal phenotypes from the pool of apparently homogenous neural crest progenitor cells that form the sympathetic ganglia. There is evidence that the final chemical phenotype of autonomic ..View full abstract
We thank Dr. Heather Young for comments on the manuscript. Work in the authors' laboratory has been supported by the National Health and Medical Research Council of Australia and the Australian Research Council.