Journal article
Population-based, case-control-family design to investigate genetic and environmental influences on melanoma risk
AE Cust, H Schmid, JA Maskiell, J Jetann, M Ferguson, EA Holland, C Agha-Hamilton, MA Jenkins, J Kelly, RF Kefford, GG Giles, BK Armstrong, JF Aitken, JL Hopper, GJ Mann
American Journal of Epidemiology | Published : 2009
DOI: 10.1093/aje/kwp307
Abstract
Discovering and understanding genetic risk factors for melanoma and their interactions with phenotype, sun exposure, and other risk factors could lead to new strategies for melanoma control. This paper describes the Australian Melanoma Family Study, which uses a multicenter, population-based, case-control-family design. From 2001 to 2005, the authors recruited 1,164 probands including 629 cases with histopathologically confirmed, first-primary cutaneous melanoma diagnosed before age 40 years, 240 population-based controls frequency matched for age, and 295 spouse/friend controls. Information on lifetime sun exposure, phenotype, and residence history was collected for probands and nearly 4,00..
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Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (NHMRC) (project grants 107359 and 211172 and program grant 402761 to G. J. M. and R. F. K.); the Cancer Councils of New South Wales (project grants 77/00 and 06/10), Victoria, and Queensland (project grant 371); and the US National Institutes of Health (RO1 grant CA-83115-01A2 to the international Melanoma Genetics Consortium (GenoMEL)). A. E. C. is the recipient of a NHMRC public health post-doctoral fellowship (no. 520018) and a Victorian Cancer Agency Early Career Seed Grant (ECSG07_010). B. K. A.'s research was supported by a University of Sydney Medical Foundation Program Grant, and J. L. H. is an Australia Fellow of the NHMRC.