Journal article
The 18F-FDG PET cingulate island sign and comparison to 123I-β-CIT SPECT for diagnosis of dementia with lewy bodies
ML Seok, A Katsifis, VL Villemagne, R Best, G Jones, M Saling, J Bradshaw, J Merory, M Woodward, M Hopwood, CC Rowe
Journal of Nuclear Medicine | SOC NUCLEAR MEDICINE INC | Published : 2009
Abstract
Neuroimaging is increasingly used to supplement the clinical diagnosis of dementia with Lewy bodies (DLB) by showing reduced occipital metabolism and perfusion and reduced striatal dopaminergic innervation. We aimed to optimize the interpretation of 18F-FDG PET images for differentiating DLB from Alzheimer disease (AD) and to compare the results with dopamine transporter imaging using 123I-β-carbomethoxy-3β-(4-iodophenyl)-tropane (123I-β-CIT) SPECT. Methods: Fourteen subjects with a clinical diagnosis of DLB and 10 with AD underwent both 18FFDG PET and 123I-β-CIT SPECT. Four DLB and 1 AD diagnoses were subsequently confirmed at autopsy. Diagnostic accuracy was calculated for visual interpret..
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Funding Acknowledgements
We acknowledge the Australian Institute of Nuclear Science and Engineering (AINSE) for funding the purchase of <SUP>123</SUP>I; ANSTO, and in particular Vahan Papazian and Tim Jackson, for the preparation of <SUP>123</SUP>I-beta-CIT; and Guildford Pharmaceuticals (USA) for providing the beta-CIT stannane for this work. Financial support was also provided by the Austin Hospital Medical Research Foundation.