Journal article
Sensitivity to MK-801 in phospholipase C-Β1 knockout mice reveals a specific NMDA receptor deficit
L Gray, CE McOmish, E Scarr, B Dean, AJ Hannan
International Journal of Neuropsychopharmacology | Published : 2009
Abstract
Phospholipase C-1 (PLC-1) is a critical component of multiple signalling pathways downstream of neurotransmitter receptors. Mice lacking this enzyme display a striking behavioural phenotype with relevance to human psychiatric disease. Glutamatergic dysfunction is strongly associated with several abnormal behavioural states and may underlie part of the phenotype of the phospholipase C-1 knockout (KO) mouse. A heightened response to glutamatergic psychotomimetic drugs is a critical psychosis-related endophenotype, and in this study it was employed as a correlate of glutamatergic dysfunction. Control (n=8) and PLC-1 KO mice (n=6) were treated with MK-801, a NMDA receptor (NMDAR) antagonist, fol..
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Funding Acknowledgements
The authors thank H.-S. Shin for providing breeder mice to establish the colony, and M. Howard and J. Nithianantharajah for their input into mouse colony management and data analysis. This work was supported by project grants and a R.D. Wright award to A.J.H. from the National Health and Medical Research Council of Australia. AJ.H. is also the recipient of a Pfizer Australia Fellowship. B.D. is a NHMRC Senior Research Fellow, and E.S. is the Ronald Phillip Griffith Schizophrenia Research Fellow.