Journal article
A biomolecular "ship-in-a-bottle": Continuous RNA synthesis within hollow polymer hydrogel assemblies
AD Price, AN Zelikin, KL Wark, F Caruso
Advanced Materials | Published : 2010
Abstract
The use of micrometer-sized, monodisperse polymer hydrogel capsules that act as both microreactors and drug carriers for de novo synthesized RNA is demonstrated (see figure). These capsules are expected to have broad impact as biophysical tools for the study of encapsulated RNA and as new biocompatible delivery vehicles for the cellular delivery of RNA therapeutics. 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Grants
Funding Acknowledgements
This work was supported by the Australian Research Council under the Federation Fellowship and Discovery Project schemes. We thank A. Becker for useful discussions, K. Breheney for technical assistance, and K. Ladewig for critically reading the manuscript. Supporting Information is available online from Wiley InterScience or from the author.