Journal article
An MRI study of the superior temporal subregions in patients with current and past major depression
T Takahashi, M Yücel, V Lorenzetti, M Walterfang, Y Kawasaki, S Whittle, M Suzuki, C Pantelis, NB Allen
Progress in Neuro Psychopharmacology and Biological Psychiatry | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2010
Abstract
The superior temporal gyrus (STG), especially its lateral portion, and temporal pole (TP) both play a central role in emotional processing, but it remains largely unknown whether patients with major depressive disorder (MDD) exhibit morphologic changes in these regions. We delineated the STG subregions [planum polare (PP), Heschl gyrus (HG), planum temporale (PT), rostral STG, and caudal STG] and TP using magnetic resonance imaging in 29 currently depressed patients (mean age = 32.5 years, 7 males), 27 remitted depressed patients (mean age = 35.1 years, 9 males), and 33 age- and gender-matched healthy control subjects (mean age = 34.0 years, 12 males). Both current and remitted MDD patients ..
View full abstractGrants
Awarded by Australian Research Council
Awarded by NHMRC Clinical Career Development Award
Awarded by Japanese Society for the Promotion of Science
Awarded by Ministry of Health and Welfare
Funding Acknowledgements
This research was supported by a grant from the Australian Research Council (I.D. DP0557663) awarded to A/Prof. Allen and A/Prof Yucel. Neuroimaging analysis was facilitated by the Neuropsychiatry Imaging Laboratory managed by Ms. Bridget Soulsby at the Melbourne Neuropsychiatry Centre and supported by Neurosciences Victoria. The authors thank Ms. Orli Schwartz and Ms. Diana Maud for the recruitment and assessment of the participants. A/Prof. Yacel is supported by an NHMRC Clinical Career Development Award (I.D. 509345). Ms. Lorenzetti is supported by a scholarship of the Faculty of Psychology, The University of Bologna, Italy. Dr. Walterfang was supported by a Pfizer Neuroscience Research Grant and a Stanley Research Centre Grant. Dr. Whittle was supported by an Australian Research Council Postdoctoral Fellowship. Dr. Takahashi was supported to undertake this work by a Grant-in-Aid for Scientific Research (No. 19591346) from the Japanese Society for the Promotion of Science; and a Research Grant (17-2, 18-6) for Nervous and Mental Disorders from the Ministry of Health and Welfare (Dr. Suzuki), Japan. A/Prof Allen is supported by a grant from the Colonial Foundation.