Journal article
Uteroplacental insufficiency causes a nephron deficit, modest renal insufficiency but no hypertension with ageing in female rats
KM Moritz, MQ Mazzuca, AL Siebel, A Mibus, D Arena, M Tare, JA Owens, ME Wlodek
Journal of Physiology | WILEY | Published : 2009
Abstract
In rats, uteroplacental insufficiency induced by uterine vessel ligation restricts fetal growth and impairs mammary development compromising postnatal growth. In male offspring, this results in a nephron deficit and hypertension which can be reversed by improving lactation and postnatal growth. Here, growth, blood pressure and nephron endowment in female offspring from mothers which underwent bilateral uterine vessel ligation (Restricted) on day 18 of pregnancy were examined. Sham surgery (Control) and a reduced litter group (Reduced at birth to 5, equivalent to Restricted group) were used as controls. Offspring (Control, Reduced, Restricted) were cross-fostered on postnatal day 1 onto a Con..
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Funding Acknowledgements
The authors would like to thank Channel 7, the National Heart Foundation of Australia, the National Health and Medical Research Council of Australia (NH&MRC) and The University of Melbourne for grant support. Karen Moritz was supported by a NH&MRC Career Development Award and Andrew Siebel by a NH&MRC Peter Doherty Fellowship. Marc Mazzuca was supported by a Kidney Health Biomedical Scholarship and The University of Melbourne Fee Remission Scholarship. We also thank Kerryn Westcott, Chris Chiu, Andrew Jefferies and Alexis Marshall for their assistance and Associate Professor Helena Parkington for her contributions.