Journal article

Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice

Elisabeth Huijsman, Caro van de Par, Catherine Economou, Chris van der Poel, Gordon S Lynch, Gabriele Schoiswohl, Gunter Haemmerle, Rudolf Zechner, Matthew J Watt

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | AMER PHYSIOLOGICAL SOC | Published : 2009

Abstract

Adipose triacylglycerol lipase (ATGL) and hormone-sensitive lipase (HSL) are essential for efficient lipolysis in adipose tissue and skeletal muscle. Herein, we utilized whole body knockout mice to address the importance of ATGL and HSL for metabolic function and exercise performance. ATGL deletion severely disrupts whole-body substrate partitioning at rest; reducing plasma free fatty acid (FFA) availability (WT: 0.49 +/- 0.06 vs. ATGL(-/-) 0.34 +/- 0.03 mM), which in turn enhances carbohydrate oxidation during fasting (mean RER, WT: 0.86 +/- 0.02, ATGL(-/-) 0.90 +/- 0.01) and is associated with depleted muscle and liver glycogen stores. While plasma FFA was modestly reduced (23%) and whole ..

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University of Melbourne Researchers