Heritable pathologic cardiac hypertrophy in adulthood is preceded by neonatal cardiac growth restriction
Enzo R Porrello, James R Bell, Jonathan D Schertzer, Claire L Curl, Julie R McMullen, Kimberley M Mellor, Rebecca H Ritchie, Gordon S Lynch, Stephen B Harrap, Walter G Thomas, Lea MD Delbridge
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2009
The identification of genetic factors influencing cardiac growth independently of increased load is crucial to an understanding of the molecular and cellular basis of pathological cardiac hypertrophy. The central aim of this investigation was to determine how pathological hypertrophy in the adult can be linked with disturbances in cardiomyocyte growth and viability in early neonatal development. The hypertrophic heart rat (HHR) model is derived from the spontaneously hypertensive rat and exhibits marked cardiac hypertrophy, in the absence of a pressure load at maturity. Hearts were harvested from male HHR, and control strain normal heart rats (NHR), at different stages of postnatal developme..View full abstract
This work was supported by the National Health and Medical Research Council of Australia, the Australian Research Council and the Wenkart Foundation. Career support ( to E. R. Porrello) provided by an Australian Postgraduate Award and a Baker Foundation Postgraduate Award ( Henry Cooper Scholarship).