A DTI-derived measure of cortico-cortical connectivity

A Zalesky; A Fornito

Journal article

A DTI-derived measure of cortico-cortical connectivity

A Zalesky, A Fornito

IEEE Transactions on Medical Imaging | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC | Published : 2009

DOI: 10.1109/TMI.2008.2012113

Abstract

We arm researchers with a simple method to chart a macroscopic cortico-cortical connectivity network in living human subjects. The researcher provides a diffusion-magnetic resonance imaging (MRI) data set and N cortical regions of interest. In return, we provide an N x N structural adjacency matrix (SAM) quantifying the relative connectivity between all cortical region pairs. We also return a connectivity map for each pair to enable visualization of interconnecting fiber bundles. The measure of connectivity we devise is: 1) free of length bias, 2) proportional to fiber bundle cross-sectional area, and 3) invariant to an exchange of seed and target. We construct a 3-D lattice scaffolding (gra..

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University of Melbourne Researchers

Andrew Zalesky Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

Manuscript received October 08, 2008; revised November 26, 2008. First published January 13, 2009; current version published June 24, 2009. The work of A. Zalesky was supported by the Australian Research Council (ARC) under Linkage Project LX0882154 and Discovery Project DP0986320. The work of A. Fornito was supported by a National Health and Medical Research Council C. J. Martin Fellowship (454797). Asterisk indicates corresponding author.