Journal article

Progressive Gray Matter Reduction of the Superior Temporal Gyrus During Transition to Psychosis

Tsutomu Takahashi, Stephen J Wood, Alison R Yung, Bridget Soulsby, Patrick D McGorry, Michio Suzuki, Yasuhiro Kawasaki, Lisa J Phillips, Dennis Velakoulis, Christos Pantelis

ARCHIVES OF GENERAL PSYCHIATRY | AMER MEDICAL ASSOC | Published : 2009

Abstract

CONTEXT: Longitudinal magnetic resonance imaging studies have shown progressive gray matter reduction in the superior temporal gyrus during the earliest phases of schizophrenia. It is unknown whether these progressive processes predate the onset of psychosis. OBJECTIVE: To examine gray matter reduction of the superior temporal gyrus over time in individuals at risk for psychosis and in patients with first-episode psychosis. DESIGN: Cross-sectional and longitudinal comparisons. SETTING: Personal Assessment and Crisis Evaluation Clinic and Early Psychosis Preventions and Intervention Centre. PARTICIPANTS: Thirty-five ultrahigh-risk individuals (of whom 12 later developed psychosis [UHRP] and 2..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Japanese Society for the Promotion of Science


Awarded by Ministry of Health and Welfare, Japan


Funding Acknowledgements

This study was supported by project grants from the National Health and Medical Research Council (NHMRC; grants 145627, 145737, 970598, 981112, and 970391), NHMRC Program Grant 350241, and Colonial Foundation. Drs Velakoulis and Wood were supported as research officers with funding from the NHMRC. Dr McGorry was supported by a National Alliance for Research on Schizophrenia and Depression (NARSAD) Distinguished Investigator Award. Dr Wood is currently supported by Clinical Career Development Award 359223 from the NHMRC and a NARSAD Young Investigator Award. Dr Takahashi was supported to undertake this work by Grant-in-Aid for Scientific Research 19591346 from the Japanese Society for the Promotion of Science (Dr Takahashi), and research grant 17-2, 18-6 for Nervous and Mental Disorders from the Ministry of Health and Welfare, Japan (Dr Suzuki).