Long-Term Persistence of Tissue-Engineered Adipose Flaps in a Murine Model to 1 Year: An Update
Michael W Findlay, Aurora Messina, Erik W Thompson, Wayne A Morrison
PLASTIC AND RECONSTRUCTIVE SURGERY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2009
BACKGROUND: Tissue engineering of patient-specific adipose tissue has the potential to revolutionize reconstructive surgery. Numerous models have been described for the production of adipose tissue with success in the short term, but little has been reported on the stability of this tissue-engineered fat beyond 4 months. METHODS: A murine model of de novo adipogenesis producing a potentially transplantable adipose tissue flap within 4 to 6 weeks was developed in the authors' laboratory. In this study, the authors assess the ability of three-chamber (44-microl volume) configurations shown to be adipogenic in previous short-term studies (autograft, n = 8; open, n = 6; fat flap, n = 11) to main..View full abstract
Supported by grants from the National Health & Medical Research Council of Australia and the National Australia Bank. Dr. Findlay was supported by scholarships from the National Health & Medical Research Council of Australia, the Royal Australasian College of Surgeons, and the University of Melbourne. We would like to gratefully acknowledge the surgical assistance of Sue McKay, Liliana Pepe, Amanda Rixon, and Anna Deftereos of the Experimental Medical Surgical Unit, St. Vincent's Hospital Melbourne.