Expression and evolutionary conservation of the tescalcin gene during development
Yong Bao, Quanah J Hudson, Erasmo M Perera, Leonardo Akan, Stuart A Tobet, Craig A Smith, Andrew H Sinclair, Gary D Berkovitz
GENE EXPRESSION PATTERNS | ELSEVIER SCIENCE BV | Published : 2009
The tescalcin gene (Tesc) encodes an EF-hand calcium-binding protein that interacts with the sodium/hydrogen exchanger, NHE1. Previous studies indicated that Tesc was expressed in mouse embryonic testis, but not in ovary, during the critical period of testis and ovary determination. In this paper we compared the expression of Tesc in embryonic tissues of chicken and mouse. Tesc expression was sexually dimorphic in the embryonic gonads of both mouse and chicken. Tescalcin (TESC) was detected in both Sertoli cells and germ cells. In the embryonic brain of both mouse and chicken, Tesc was highly expressed in the nasal placode and in fibers extending from the olfactory epithelium to the primordi..View full abstract
This work was supported by the Department of Pediatrics, Miller School of Medicine at University of Miami and the Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.