Journal article

The identification of leptin-derived peptides that are taken up by the brain

Graham L Barrett, Jennifer Trieu, Tim Naim

REGULATORY PEPTIDES | ELSEVIER SCIENCE BV | Published : 2009

Abstract

We studied the brain uptake of leptin and of a set of peptides whose combined sequences spanned the entire mature human leptin protein. We compared their uptake to that of albumin and IgG. Two of these peptides, consisting of residues 1-33 and 61-90, demonstrated brain uptake on a par with leptin protein itself, and significantly higher than the uptake of albumin and IgG. Further investigation revealed a peptide, 12-32, with higher uptake than its parent peptide 1-33. Peptide 61-90 had the highest brain uptake, and this was shown to be saturable. Comparison of these brain-permeant peptides with the published structure of the leptin:leptin receptor complex revealed a high degree of correlatio..

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University of Melbourne Researchers