5-HT antagonists NAN-190 and SB 269970 block alpha(2)-adrenoceptors in the guinea pig
Jaime Pei Pei Foong, Joel C Bornstein
NEUROREPORT | LIPPINCOTT WILLIAMS & WILKINS | Published : 2009
Serotonin (5-HT) plays a significant role in the regulation of intestinal secretion of water and electrolytes. The initial aim of this study was to use intracellular recording and specific antagonists to identify roles of 5-HT1A and 5-HT7 receptors of submucosal noncholinergic secretomotor neurons of guinea pig ileum, in vitro. However, it was found that the widely used 5-HT receptor antagonists NAN-190 (5-HT1A) and SB 269970 (5-HT7) both blocked alpha2-adrenoceptors, and hence depressed inhibitory synaptic potentials and hyperpolarizations evoked by noradrenaline, in these neurons. Both compounds enhanced neurally evoked contractions of the guinea pig vas deferens, an effect characteristic ..View full abstract
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Awarded by National Health and Medical Research Council Australia
The study was supported by a grant from the National Health and Medical Research Council Australia (NHMRC Grant No. 40053) and an Australian Postgraduate Award (J.P.P.).