5-HT antagonists NAN-190 and SB 269970 block α2- adrenoceptors in the guinea pig

JPP Foong; JC Bornstein

Journal article

5-HT antagonists NAN-190 and SB 269970 block α2- adrenoceptors in the guinea pig

JPP Foong, JC Bornstein

Neuroreport | Published : 2009

DOI: 10.1097/WNR.0b013e3283232caa

Abstract

Serotonin (5-HT) plays a significant role in the regulation of intestinal secretion of water and electrolytes. The initial aim of this study was to use intracellular recording and specific antagonists to identify roles of 5-HT 1A and 5-HT7 receptors of submucosal noncholinergic secretomotor neurons of guinea pig ileum, in vitro. However, it was found that the widely used 5-HT receptor antagonists NAN-190 (5-HT1A) and SB 269970 (5-HT7) both blocked α2- adrenoceptors, and hence depressed inhibitory synaptic potentials and hyperpolarizations evoked by noradrenaline, in these neurons. Both compounds enhanced neurally evoked contractions of the guinea pig vas deferens, an effect characteristic of..

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University of Melbourne Researchers

Joel Bornstein Author

Related Projects (1)

Neural coordination of intestinal motility and mucosal secretion of water and salt - role in toxin induced diarrhoea

This project deals with some of the basic mechanisms underlying disorders of gastrointestinal function and in particular with the mechanisms..

Grants

Awarded by National Health and Medical Research Council Australia

Funding Acknowledgements

The study was supported by a grant from the National Health and Medical Research Council Australia (NHMRC Grant No. 40053) and an Australian Postgraduate Award (J.P.P.).