Reactive oxygen species and insulin-resistant cardiomyopathy

Abstract

1. The prevalence of insulin resistance has increased markedly in the past decade and is known to be associated with cardiovascular risk. Evidence of an insulin-resistant cardiomyopathy, independent of pressure or volume loading influences, is now emerging. 2. Cardiac oxidative stress is often observed coincident with insulin resistance and there is accumulating evidence that reactive oxygen species (ROS) mediate deleterious effects in the insulin-resistant heart. It is established that ROS modification of signalling proteins can adversely modulate cellular processes, leading to cardiac growth remodelling and dysfunction. The mechanisms of ROS-induced damage in insulin-resistant cardiomyopat..