Cell lineage tree models of neurogenesis

Abstract

The production of neurons to form the mammalian cortex, known as embryonic cortical neurogenesis, is a complex developmental process. Insight into the process of cell division during neurogenesis is provided by murine cortical cell lineage trees, recorded through experimental observation. Recurring patterns within cell lineage trees may be indicative of predetermined cell behaviour. The application of mathematical modelling to this process requires careful consideration and identification of the key features to be incorporated into the model. A biologically plausible stochastic model of evolution of cell lineage trees is developed, based on the most important known features of neurogenesis. ..