Journal article

THE POPCORN WOLBACHIA INFECTION OF DROSOPHILA MELANOGASTER: CAN SELECTION ALTER WOLBACHIA LONGEVITY EFFECTS?

Lauren B Carrington, Jane Leslie, Andrew R Weeks, Ary A Hoffmann

EVOLUTION | WILEY | Published : 2009

Abstract

Wolbachia popcorn (wMelPop), a life-shortening strain of Wolbachia, has been proposed as an agent for suppressing transmission of dengue fever following infection of the vectoring mosquito Aedes aegypti. However, evolutionary changes in the host and Wolbachia genomes might attenuate any life span effects mediated by wMelPop. Here we test for attenuation by selecting strains of Drosophila melanogaster infected with wMelPop for early and late reproduction in three independent outcrossed populations. Selection caused divergence among the lines in longevity. This divergence was mostly associated with the host genetic background rather than the Wolbachia infection, although there were also intera..

View full abstract

Grants

Funding Acknowledgements

LBC would like to thank C. Doig and P. Mitrovski for their help in the experiments. R. Hallas and M. Schiffer set up the original lines that all work was based on. This research was supported by a grant from the Foundation for the National Institutes of Health through the Grand Challenges in Global Health Initiative of the Bill and Melinda Gates Foundation, and funding from the Australian Research Council via their Special Research Centre Program. This work was carried out while AAH held an Australian Federation Fellowship.