Journal article

A portrait of the "SCP/TAPS" proteins of eukaryotes - Developing a framework for fundamental research and biotechnological outcomes

C Cantacessi, BE Campbell, A Visser, P Geldhof, MJ Nolan, AJ Nisbet, JB Matthews, A Loukas, A Hofmann, D Otranto, PW Sternberg, RB Gasser



A wide range of proteins belonging to the SCP/TAPS "family" has been described for various eukaryotic organisms, including plants and animals (vertebrates and invertebrates, such as helminths). Although SCP/TAPS proteins have been proposed to play key roles in a number of fundamental biological processes, such as host-pathogen interactions and defence mechanisms, there is a paucity of information on their genetic relationships, structures and functions, and there is no standardised nomenclature for these proteins. A detailed analysis of the relationships of members of the SCP/TAPS family of proteins, based on key protein signatures, could provide a foundation for investigating these areas. I..

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Awarded by Australian Research Council

Funding Acknowledgements

The research was supported by the Australian Research Council (ARC) (DP0665230; RBG and AL), the Australian Academy of Science and the Australian-American Fulbright Commission (RBG). JBM and AJN are funded by the Scottish Government RERAD. CC was the grateful recipient of a Dr Sue Newton Scholarship and an International Postgraduate Research Scholarship (IPRS) from the Australian Government via The University of Melbourne. PG is a Postdoctoral Fellow of the Fund for Scientific Research - Flanders (Belgium) (F.W.C. - Vlaanderen).