Journal article

Effect of local, long-term delivery of platelet-derived growth factor (PDGF) on injected fat graft survival in severe combined immunodeficient (SCID) mice

Randall O Craft, John Rophael, Wayne A Morrison, Aditya V Vashi, Geraldine M Mitchell, Anthony J Penington

JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY | ELSEVIER SCI LTD | Published : 2009

Abstract

SUMMARY BACKGROUND: Autogenous fat injection is widely used for the correction of acquired and congenital soft tissue defects. However, the high absorption rate results in the need for over-correction of the defect and repeat procedures. We hypothesised that platelet-derived growth factor (PDGF), a potent mitogen and known stimulant for murine preadipocytes, would improve fat graft survival when concentrations were sustained with a gelatine microsphere delivery system. METHODS: Abdominal fat was harvested from an otherwise healthy 43-year-old woman during a breast reconstruction. Prior to subdermal injection into severe combined immunodeficient (SCID) mice, the fat grafts were divided into 1..

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