Journal article

Brain surface contraction mapped in first-episode schizophrenia: a longitudinal magnetic resonance imaging study

D Sun, GW Stuart, M Jenkinson, SJ Wood, PD McGorry, D Velakoulis, TGM van Erp, PM Thompson, AW Toga, DJ Smith, TD Cannon, C Pantelis

MOLECULAR PSYCHIATRY | NATURE PUBLISHING GROUP | Published : 2009

Abstract

Schizophrenia is associated with structural brain abnormalities, but the timing of onset and course of these changes remains unclear. Longitudinal magnetic resonance imaging (MRI) studies have demonstrated progressive brain volume decreases in patients around and after the onset of illness, although considerable discrepancies exist regarding which brain regions are affected. The anatomical pattern of these progressive changes in schizophrenia is largely unknown. In this study, MRI scans were acquired repeatedly from 16 schizophrenia patients approximately 2 years apart following their first episode of illness, and also from 14 age-matched healthy subjects. Cortical Pattern Matching, in combi..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by NIH


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Awarded by NATIONAL INSTITUTE ON AGING


Awarded by NATIONAL LIBRARY OF MEDICINE


Funding Acknowledgements

This research was supported by project grants from the Australian National Health and Medical Research Council (NHMRC; Grant IDs: 145627, 145737, 970598, 981112, 970391), NHMRC Program Grant ( ID: 350241), Victorian Health Promotion Foundation, the Stanley Foundation and Ian Potter Foundation. Drs Velakoulis and Wood were supported as Research Officers with funding from the NHMRC. Dr McGorry was supported by a NARSAD Distinguished Investigator Award. Dr Wood is currently supported by a Clinical Career Development Award from the NHMRC ( ID: 359223) and a NARSAD Young Investigator Award. Dr Thompson is supported by NIH Grants AG016570, LM05639, EB01651 and RR019771. Image analysis and statistical analysis were supported by NIH Grants MH65078 to Dr Cannon and RR021813 ( Center for Computational Biology) to Dr Toga. Dr Jenkinson is supported by the UK EPSRC and BBSRC.