Amygdala volumes in a sample of current depressed and remitted depressed patients and healthy controls
Valentina Lorenzetti, Nicholas B Allen, Sarah Whittle, Murat Yuecel
JOURNAL OF AFFECTIVE DISORDERS | ELSEVIER SCIENCE BV | Published : 2010
BACKGROUND: Major Depressive Disorder is associated with amygdala volumetric alterations. To date, it is still unclear (I) whether amygdala volumetric alterations constitute a state or a trait marker of MDD; (II) what influences the direction of amygdala morphometric changes (i.e., enlargement versus shrinkage); and (III) what the role of laterality is in amygdala volumetric alterations in MDD. METHODS: We investigated amygdala volume in a sample of 31 currently depressed patients (cMDD), 31 healthy subjects with a previous diagnosis of MDD (rMDD) and 31 healthy controls, using images obtained from a 1.5 Tesla MRI scanner. The groups were matched for age and gender. RESULTS: We found that le..View full abstract
Awarded by National Health & Medical Research Council (NH&MRC) of Australia
Awarded by Australian Research Council
Awarded by National Health and Medical Research Council
Valentina Lorenzetti is supported by the Endeavour international Postgraduate Research Scholarship (IPRS) and the Melbourne International Research Scholarship (MIRS). Murat Yucel is supported by a National Health & Medical Research Council (NH&MRC) of Australia Clinical Career Development Award (I.D. 509345). Nick Allen and Murat Yucel are supported by the Colonial Foundation. Sarah Whittle is supported by the Australian Research Council Postdoctoral Fellowship (I.D. DP0878136). All grants had no further role in study design; in the collection, analysis and interpretation of data: in the writing of the report; and in the decision to submit the paper for publication.Neuroimaging analysis was facilitated by the Neuropsychiatry Imaging Laboratory at the Melbourne Neuropsychiatry Centre, which is managed by Mr Chester Kang and Ms Bridget Soulsby, supported by Neurosciences Victoria, the National Health and Medical Research Council (I.D. 236175) and the Ian Potter Foundation, Melbourne, Australia.