Journal article

Engineered antibody intervention strategies for Alzheimer's disease and related dementias by targeting amyloid and toxic oligomers

Remy Robert, Olan Dolezal, Lynne Waddington, Meghan K Hattarki, Roberto Cappai, Colin L Masters, Peter J Hudson, Kim L Wark

Protein Engineering Design & Selection | OXFORD UNIV PRESS | Published : 2009

DOI: 10.1093/protein/gzn052

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Keywords

Antibody Affinity
Amino Acid Sequence
Amyloid Beta Modulation
Biotechnology & Applied Microbiology
Chain Variable Fragments
Spr
In-Vivo
Amyloid Beta-Peptides
Precursor Protein
Mouse Model
Immunoglobulin Variable Region
Alzheimer'S Disease (ad)
Science & Technology
Escherichia Coli
Protein Stability
Models, Molecular
Alzheimer Disease
Kinetics
Cell Line
Crystal-Structure
Molecular Sequence Data
Mutagenesis, Site-Directed
Molecular-Mass Multimers
Surface Plasmon Resonance
Amyloid
Immunization, Passive
Life Sciences & Biomedicine
A-Beta Peptide
Stability
Fibril Formation
Biochemistry & Molecular Biology
Central-Nervous-System
Peptide Fragments
Recombinant Fusion Proteins
Engineered Antibody
Atomic-Force Microscopy
Cell Survival
Immunoglobulin Fab Fragments