A beta(1-42) stimulates adult SVZ neurogenesis through the p75 neurotrophin receptor
Areechun Sotthibundhu, Qiao-Xin Li, Wipawan Thangnipon, Elizabeth J Coulson
Neurobiology of Aging | ELSEVIER SCIENCE INC | Published : 2009
The generation of amyloid-beta peptide (Abeta) and its accumulation in amyloid plaques are generally recognized as key characteristics of Alzheimer's disease. A number of reports have indicated that Abeta can regulate the proliferation of neural precursor cells and adult neurogenesis, suggesting that this may underpin the cognitive decline and compromised olfaction also associated with the condition. Here we report that Abeta(1-42) treatment both in vitro and in vivo, as well as endogenous generation of Abeta in C100 and APP/PS1 transgenic models of Alzheimer's disease, stimulate neurogenesis of young adult subventricular zone precursors. The neurogenic effect of Abeta(1-42) was found to req..View full abstract
The National Health and Medical Research Council of Australia supported this work. AS is the recipient of a Development and Promotion of Science and Technology Talent Scholarship, Mahidol University, Thailand. We would like to thank Briony Fox for performing surgical procedures and Rowan Tweedale for editorial assistance.