Aβ1-42 stimulates adult SVZ neurogenesis through the p75 neurotrophin receptor

Abstract

The generation of amyloid-beta peptide (Aβ) and its accumulation in amyloid plaques are generally recognized as key characteristics of Alzheimer's disease. A number of reports have indicated that Aβ can regulate the proliferation of neural precursor cells and adult neurogenesis, suggesting that this may underpin the cognitive decline and compromised olfaction also associated with the condition. Here we report that Aβ1-42 treatment both in vitro and in vivo, as well as endogenous generation of Aβ in C100 and APP/PS1 transgenic models of Alzheimer's disease, stimulate neurogenesis of young adult subventricular zone precursors. The neurogenic effect of Aβ1-42 was found to require expression of ..