Journal article
Positron emission tomography changes management, improves prognostic stratification and is superior to gallium scintigraphy in patients with low-grade lymphoma: Results of a multicentre prospective study
AM Scott, DH Gunawardana, J Wong, I Kirkwood, RJ Hicks, I Ho Shon, JE Ramshaw, P Robins
European Journal of Nuclear Medicine and Molecular Imaging | SPRINGER | Published : 2009
Abstract
Purpose: Positron emission tomography (PET) was evaluated in low-grade non-Hodgkin lymphoma (NHL) to determine its impact on staging and management and to compare PET and gallium scans. Methods: PET resulted in management plan changes in 74 patients with untreated low-grade NHL stages I to III. Patient outcomes to 12 months were documented. Results: PET identified additional lesions in 50% of patients, led to a change in stage in 32%, and had a significant impact on management in 34%. Inferior progression-free survival was noted in patients with additional lesions detected by PET (p=0.001) and in the 28% of patients upstaged by PET to stage III or IV (p=0.024). In a subset of 16 patients und..
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Funding Acknowledgements
The authors wish to acknowledge the Australian Government Department of Health and Ageing for funding, and the Australian and New Zealand Association of Physicians in Nuclear Medicine for managing, the PET Data Collection Project, and to acknowledge Amanda Byrne, Andrew Chicco, Terri Davies, Elizabeth Drummond, Sonia Harwood and Debbie Lennon and the staff of the PET centres involved in the study for their contribution.