Journal article

Substantiating in vivo magnetic brain tumor targeting of cationic iron oxide nanocarriers via adsorptive surface masking

Beata Chertok, Allan E David, Bradford A Moffat, Victor C Yang

Biomaterials | ELSEVIER SCI LTD | Published : 2009

Abstract

Cationic magnetic nanoparticles are attractive as potential vehicles for tumor drug delivery due to their favorable interactions with both the tumor milieu and the therapeutic cargo. However, systemic delivery of these nanoparticles to the tumor site is compromised by their rapid plasma clearance. We developed a simple method for in vivo protection of cationic nanocarriers, using non-covalent surface masking with a conjugate of low molecular weight heparin and polyethylene glycol. Surface masking resulted in a 11-fold increase in plasma AUC and a 2-fold increase in the magnetic capture of systemically injected nanoparticles in orthotopic rodent brain tumors. Overall, the described methodolog..

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University of Melbourne Researchers

Grants

Awarded by NIH


Awarded by Australian NHMRC RD Wright Fellowship


Awarded by NATIONAL CANCER INSTITUTE


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Funding Acknowledgements

We thank Dr. Christian Bergemann from Chernicell (Germany) for the generous gift of iron oxide nanoparticles. We acknowledge the Center for Molecular Imaging at the University of Michigan for providing access to the MRI facility. This work was supported in part by NIH R01 Grants CA114612 and NS066945, as well as a research grant from the Hartwell Foundation. Victor C. Yang is currently appointed by the Chinese Ministry of Education as the Chang Kang Scholar at Tianjin University, Tianjin, China. Beata Chertok was a recipient of the University of Michigan Rackham Graduate School Pre-doctoral Fellowship. Bradford Moffat is supported by an Australian NHMRC RD Wright Fellowship 454790.