Journal article

A Feasibility Study of Parametric Response Map Analysis of Diffusion-Weighted Magnetic Resonance Imaging Scans of Head and Neck Cancer Patients for Providing Early Detection of Therapeutic Efficacy

Craig J Galban, Suresh K Mukherji, Thomas L Chenevert, Charles R Meyer, Daniel A Hamstra, Peyton H Bland, Timothy D Johnson, Bradford A Moffat, Alnawaz Rehemtulla, Avraham Eisbruch, Brian D Ross

TRANSLATIONAL ONCOLOGY | ELSEVIER SCIENCE INC | Published : 2009

Abstract

The parametric response map (PRM) was evaluated as an early surrogate biomarker for monitoring treatment-induced tissue alterations in patients with head and neck squamous cell carcinoma (HNSCC). Diffusion-weighted magnetic resonance imaging (DW-MRI) was performed on 15 patients with HNSCC at baseline and 3 weeks after treatment initiation of a nonsurgical organ preservation therapy (NSOPT) using concurrent radiation and chemotherapy. PRM was applied on serial apparent diffusion coefficient (ADC) maps that were spatially aligned using a deformable image registration algorithm to measure the tumor volume exhibiting significant changes in ADC (PRM(ADC)). Pretherapy and midtherapy ADC maps, qua..

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University of Melbourne Researchers