Journal article

Expression and localization of the Parkin Co-Regulated Gene in mouse CNS suggests a role in ependymal cilia function

Gabrielle R Wilson, Jacqueline T Tan, Kate M Brody, Juliet M Taylor, Martin B Delatycki, Paul J Lockhart



Parkin Co-Regulated Gene (PACRG) is a gene that shares a bi-directional promoter with the Parkinson's disease associated gene parkin. The functional role of PACRG is not well understood, although the gene has been associated with parkinsonian syndromes and more recently with eukaryotic cilia and flagella. We investigated the expression of Pacrg in the mouse brain by in situ hybridization and observed robust expression of Pacrg in the cells associated with the lateral, third and fourth ventricle, in addition to the aqueduct of Sylvius and choroid plexus. For all regions of Pacrg expression identified, strong expression was observed in the newborn period and this was maintained into adulthood...

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Awarded by National Health & Medical Research Council (Australia)

Awarded by GRW

Awarded by PJL

Awarded by MBD

Funding Acknowledgements

The authors acknowledge the assistance of laboratory and animal facility staff. This work was supported in part by National Health & Medical Research Council (Australia) project grants 334349 and 436977 to PJL. GRW is an NHMRC Dora Lush Scholar (384489), PJL is an NHMRC RD Wright Fellow (334346) and MBD is an NHMRC Practitioner Fellow (284520).