Thrombocytopenia Is Strongly Associated With Simian AIDS in Pigtail Macaques
Sheilajen Alcantara, Jeanette Reece, Thakshila Amarasena, Robert De Rose, Joe Manitta, Janiki Amin, Stephen J Kent
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | LIPPINCOTT WILLIAMS & WILKINS | Published : 2009
Simian AIDS has a variable time course and presentation making it difficult to define disease effects of progressive simian immunodeficiency virus (SIV) infection. We commonly observed thrombocytopenia (TCP) associated with progressive SIV infection of pigtail macaques (Macaca nemestrina). We therefore analyzed the relationship between platelet counts, viral load (VL), and CD4 T-cell levels in 44 unselected macaques with chronic SIV infection. Persistent TCP was observed in 70% of pigtail macaques infected with SIVmac251 for up to 77 weeks in the absence of clinically significant bleeding. The presence of TCP correlated with higher SIV plasma VLs and depressed total and memory CD4 T cells. T..View full abstract
Supported by the Australian National Health and Medical Research Council.