Journal article

Designing immunity to HIV: Manipulating antibody-dependent cellular cytotoxicity antibodies

G Isitman, M Navis, SJ Kent, I Stratov

HIV Therapy | Published : 2009

Abstract

The failure of HIV vaccine concepts based upon either simple antibody or T-cell immunity means that newer concepts in immunity to HIV require urgent investigation. Antibody-dependent cellular cytotoxicity (ADCC) responses, utilizing the arms of humoral and innate immunity, have been studied for many years, but their role in controlling or preventing HIV-1 remains controversial. Newer technologies can now be applied to study and map ADCC responses. This permits experiments to purify and isolate HIV-specific ADCC antibodies and directly assess their role in preventing simian-HIV infections in macaques. Analogous to complexities in the quality and specificity of T-cell and neutralizing antibody..

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University of Melbourne Researchers

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