Journal article

Wolffian duct differentiation by physiological concentrations of androgen delivered systemically (vol 334, pg 429 2009)

Marilyn B Renfree, Jane Fenelon, Gratiana Wijayanti, Jean D Wilson, Geoffrey Shaw

DEVELOPMENTAL BIOLOGY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2016

Abstract

In developing mammalian males, conversion of the Wolffian ducts into the epididymides and vasa deferentia depends on androgen secretion by the testes, whereas in females these ducts remain in a vestigial form or regress. However, there is continuing uncertainty whether the androgen needs to be delivered locally, either by diffusion from the adjacent testis or, by secretion into the lumen of the duct, or whether circulating androgens maintain and virilize the Wolffian ducts. To resolve this uncertainty, we transplanted either day 0-2 or day 8-9 post-partum testes beneath the flank skin of three groups of neonatal (days 0-1) female tammar wallabies, where they developed and secreted physiologi..

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