Association Between Early-life Factors and Risk of Child-onset Crohn's Disease Among Victorian Children Born 1983-1998: A Birth Cohort Study
Anne-Louise Ponsonby, Anthony G Catto-Smith, Angela Pezic, Sandy Dupuis, Jane Halliday, Don Cameron, Ruth Morley, John Carlin, Terry Dwyer
INFLAMMATORY BOWEL DISEASES | LIPPINCOTT WILLIAMS & WILKINS | Published : 2009
BACKGROUND: The incidence of Crohn's disease (CD) with onset before age 16 has increased. Several perinatal characteristics have been associated with CD. Our objective was to examine the temporal change in CD incidence by period of birth and the extent that this could be attributed to perinatal characteristics associated with higher CD risk. METHODS: A record linkage study was conducted utilizing the perinatal records of Victorian births 1983-1998 inclusive and a state-based CD registry. Proportional hazards models were used to investigate the perinatal factors in relation to the onset of CD by age 16. Further, a nested case control study was conducted to examine the association between sibl..View full abstract
Funded by Murdoch Childrens Research Institute internal grant.