Reduced membrane bound CD14 expression in the cord blood of infants with a family history of allergic disease
RJ Boyle, R Morley, L-J Mah, S Kivivuori, ML-K Tang
Clinical and Experimental Allergy | WILEY | Published : 2009
BACKGROUND: Infants at increased risk of allergic disease have altered immune function at birth, but the specific immune changes described differ between studies and their precise nature is not well defined. Changes affecting innate immune responses may be particularly important in allergic disease pathogenesis. OBJECTIVE: We investigated whether inherited risk of allergic disease is associated with altered markers of innate immunity, T cell regulation or dendritic cell (DC) percentage in human newborns. METHODS: Cord blood was collected from infants at low risk (no parent affected by allergic disease, n=14), intermediate risk (one affected parent, n=54) or high risk (two affected parents, n..View full abstract
Mimi Tang is supported by a Murdoch Children's Research Institute Salary Grant. Robert Boyle is supported by a University of Melbourne Baillieu Scholarship, a Murdoch Children's Research Institute Postgraduate Scholarship and a National Institute for Health Research Clinical Lectureship. Ruth Morley is supported by an Australian National Health and Medical Research Council Senior Research Fellowship. This study was funded by grants from the Jack Brockhoff Foundation, the Murdoch Children's Research Institute and the Ilhan Food Allergy Foundation. The authors are grateful to A/Prof. Susan Donath of the University of Melbourne Department of Paediatrics for advice regarding statistical analyses, to A/Prof. Susan Prescott for advice regarding laboratory methodology, to Professors Roy Robins-Browne and Patrick Holt for advice regarding study design and to Matt Burton, Michael Permezel, Val Bryant, Christine Axelrad, Sally Moore, Maggie Flood and Amy Bin Chen for their assistance in the conduct of these studies.