Journal article

Persistent bronchiolar remodeling following brief ventilation of the very immature ovine lung

Megan O'Reilly, Stuart B Hooper, Beth J Allison, Sharon J Flecknoe, Ken Snibson, Richard Harding, Foula Sozo

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2009

Abstract

Children and adults who were mechanically ventilated following preterm birth are at increased risk of reduced lung function, suggesting small airway dysfunction. We hypothesized that short periods of mechanical ventilation of very immature lungs can induce persistent bronchiolar remodeling that may adversely affect later lung function. Our objectives were to characterize the effects of brief, positive-pressure ventilation per se on the small airways in very immature, surfactant-deficient lungs and to determine whether the effects persist after the cessation of ventilation. Fetal sheep (0.75 of term) were mechanically ventilated in utero with room air (peak inspiratory pressure 40 cmH2O, posi..

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