Dynamic changes in the direction of blood flow through the ductus arteriosus at birth
Kelly J Crossley, Beth J Allison, Graeme R Polglase, Colin J Morley, Peter G Davis, Stuart B Hooper
JOURNAL OF PHYSIOLOGY-LONDON | WILEY-BLACKWELL | Published : 2009
Major cardiovascular changes occur at birth, including increased pulmonary blood flow (PBF) and closure of the ductus arteriosus (DA), which acts as a low resistance shunt between the fetal pulmonary and systemic circulations. Although the pressure gradient between these circulations reverses after birth, little is known about DA blood flow changes and whether reverse DA flow contributes to PBF after birth. Our aim was to describe the changes in PBF and DA flow before, during and after the onset of pulmonary ventilation at birth. Flow probes were implanted on the left pulmonary artery (LPA) and DA in preterm fetal sheep (n = 8) approximately 3 days before they were delivered and ventilated. ..View full abstract
The authors gratefully acknowledge the expert technical assistance of Mr A. Satragno, Ms K. Rodgers, Ms V. Zahra and Mrs A. Thiel. This study was supported by the National Health and Medical Research Council (NHMRC) of Australia and S.B.H. and G.R.P. are recipients of NHMRC and Australian Heart Research Foundation research fellowships.