Increased coated-platelet levels in chronic haemodialysis patients

Abstract

Aim: To determine if levels of coated-platelets, which are potentially pro-thrombotic, are increased in end-stage renal disease patients on haemodialysis, a condition associated with high cardiovascular disease risk. Methods: In a cross-sectional observational study, coated-platelet levels were measured by flow cytometry in 25 end-stage renal failure haemodialysis patients and 25 controls without renal disease. Associations between coated-platelet levels and clinical and biochemical factors relevant to renal and cardiovascular disease were evaluated. Results: Mean ± SD coated-platelet levels were higher in the dialysis group than in the control group (39.3 ± 14.3% vs 30.9 ± 10.3%, P = 0.02)...