Journal article

Increased Expression of ac-FoxO1 Protein in Prelabor Fetal Membranes Overlying the Cervix: Possible Role in Human Fetal Membrane Rupture

Martha Lappas, Clyde Riley, Greg E Rice, Michael Permezel



Forkhead box O proteins have critical roles in a number of cellular processes, including apoptosis. Acetylation and phosphorylation of forkhead box O proteins are posttranslational modifications that attenuate their transcriptional activity. As supracervical fetal membranes are characterized by increased cell death, the aim of this study was to compare the expression of forkhead box O1, acetylated-forkhead box O1, and Ser-256 phosphorylated forkhead box O1 at supracervical and distal site fetal membrane. Fetal membranes overlying the cervix were identified in situ in women undergoing term elective Caesarean section. Immunohistochemistry (n = 7) was used to analyze the protein expression of f..

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Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

Dr Martha Lappas is a recipient of a National Health and Medical Research Council (NHMRC) RD Wright Fellowship (grant no 454777). The work described in this manuscript was funded by the Melbourne Research Grant Scheme and ANZ Charitable Trust (Medical Research and Technology Grant). Funding for the Leica Qwin Image Analysis System was provided by the Medical Research Foundation for Women and Babies. The authors gratefully acknowledge the assistance of the Clinical Research Midwives Valerie Bryant and Sarah Mitchell, the Obstetrics and Midwifery staff of the Mercy Hospital for Women for their cooperation, and Dr Nicole Reti (from the Department of Obstetrics & Gynaecology, University of Melbourne, Mercy Hospital for Women) for her assistance with the sample collection.