Protective Memory Responses Are Modulated by Priming Events prior to Challenge
John A Rutigliano, Melissa Y Morris, Wen Yue, Rachael Keating, Richard J Webby, Paul G Thomas, Peter C Doherty
Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2010
Human infections with highly pathogenic H5N1 avian influenza A viruses in the last decade have legitimized fears of a long-predicted pandemic. We thus investigated the response to secondary infections with an engineered, but still highly virulent, H5N1 influenza A virus in the C57BL/6 mouse model. Mice primed with the H1N1 A/Puerto Rico/8/34 (PR8) virus were partially protected from lethality following respiratory infection with the modified H5N1 virus A/Vietnam/1203/04 (DeltaVn1203). In contrast, those that had been comparably exposed to the HKx31 (H3N2) virus succumbed to the DeltaVn1203 challenge, despite similarities in viral replication, weight loss, and secondary CD8(+)-T-cell response..View full abstract
Awarded by NIH
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
We thank Scott Brown for insightful suggestions and invaluable discussion and Cory Reynolds for magnificent technical assistance.This work was supported by NIH grants AI065097 (P. G. T) and RO170251 (P. C. D.) and the American Lebanese Syrian Associated Charities at SJCRH.We have no financial conflicts of interest.