Journal article

Evolution of gastrointestinal hormones: the cholecystokinin/gastrin family

Graham S Baldwin, Oneel Patel, Arthur Shulkes

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2010

Abstract

PURPOSE OF REVIEW: To describe recent advances in our understanding of the evolution of gastrointestinal hormones, with the gastrin/cholecystokinin (CCK) family as a model. RECENT FINDINGS: The release of 11 genomic sequences in the last year has provided a wealth of additional information on peptide hormone sequences. The alternative approach of reverse genetics has identified a separate class of CCK receptor ligands in the nematode Caenorhabditis elegans. SUMMARY: Three classes of ligands, insect sulfakinins, nematode neuropeptide-like proteins and vertebrate gastrins/cholecystokinins, have now been described for the family of CCK receptors. Although all terminate in an amidated phenylalan..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Institutes of Health


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Funding Acknowledgements

This work was supported in part by grants from the National Health and Medical Research Council of Australia (509074, 566555) and the National Institutes of Health (5RO1GM065926-08).