Management of poor responders: can outcomes be improved with a novel gonadotropin-releasing hormone antagonist/letrozole protocol?

Abstract

Objective: To compare the efficacy of a microdose GnRH agonist flare (ML) with a GnRH antagonist/letrozole (AL) protocol before IVF-ET in poor responders. Design: Prospective controlled trial. Setting: Private assisted reproductive technology center. Patient(s): Five hundred thirty-four infertile women classified as past or potential poor responders based on clinic-specific criteria. Intervention(s): Poor responders were prospectively assigned to an ML or AL protocol in a 2:1 ratio, respectively. Main Outcome Measure(s): Results of controlled ovarian hyperstimulation and implantation and ongoing pregnancy rates. Result(s): Patient characteristics were similar between the two protocol groups...