Management of poor responders: can outcomes be improved with a novel gonadotropin-releasing hormone antagonist/letrozole protocol?
William B Schoolcraft, Eric S Surrey, Debra A Minjarez, John M Stevens, David K Gardner
FERTILITY AND STERILITY | ELSEVIER SCIENCE INC | Published : 2008
OBJECTIVE: To compare the efficacy of a microdose GnRH agonist flare (ML) with a GnRH antagonist/letrozole (AL) protocol before IVF-ET in poor responders. DESIGN: Prospective controlled trial. SETTING: Private assisted reproductive technology center. PATIENT(S): Five hundred thirty-four infertile women classified as past or potential poor responders based on clinic-specific criteria. INTERVENTION(S): Poor responders were prospectively assigned to an ML or AL protocol in a 2:1 ratio, respectively. MAIN OUTCOME MEASURE(S): Results of controlled ovarian hyperstimulation and implantation and ongoing pregnancy rates. RESULT(S): Patient characteristics were similar between the two protocol groups...View full abstract