Journal article
Effect of sustained inflation length on establishing functional residual capacity at birth in ventilated premature rabbits
ABTE Pas, M Siew, MJ Wallace, MJ Kitchen, A Fouras, RA Lewis, N Yagi, K Uesugi, S Donath, PG Davis, CJ Morley, SB Hooper
Pediatric Research | SPRINGERNATURE | Published : 2009
Abstract
The effect of inflation length on lung aeration pattern, tidal volumes, and functional residual capacity (FRC) immediately after birth was investigated. Preterm rabbits (28 d), randomized into four groups, received a 1-, 5-, 10-, or 20-s inflation (SI) followed by ventilation with 5 cm H2O end-expiratory pressure. Gas volumes were measured by plethysmography and uniformity of lung aeration by phase contrast x-ray imaging for 7 min. The first inspiratory volume significantly (p < 0.001) increased with inflation duration from a median (IQR) of 0.2 (0.1-3.1) mL/kg for 1-s inflation to 23.4 (19.3-30.4) mL/kg for 20-s SI. The lung was uniformly aerated, and the FRC and tidal volume fully recruite..
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Funding Acknowledgements
Supported by grants from the Australian Research Council, the Australian National Health and Medical Research Council, and by a financial support from the Access to Major Research Facilities Programme. which is a component of the International Science Linkages Programme established under the Australian Government's innovation statement, Backing Australia's Ability. Arjan B. to Pas is recipient of a Ter Meulen Fund grant for working visits, Royal Netherlands Academy of Arts and Sciences, The Netherlands and recipient of a Royal Women's Hospital postgraduate scholarship. Marcus J. Kitchen is a recipient of an ARC Post-Doctoral Fellowship.