Journal article

The Influence of Obstructive Sleep Apnea and Gender on Genioglossus Activity During Rapid Eye Movement Sleep

Danny J Eckert, Atul Malhotra, Yu L Lo, David P White, Amy S Jordan

CHEST | ELSEVIER SCIENCE BV | Published : 2009

Abstract

BACKGROUND: The mechanisms contributing to worsening of obstructive sleep apnea (OSA) during rapid eye movement (REM) sleep have been minimally studied. Reduced upper-airway muscle tone may be an important contributor. Because respiratory events and the associated blood gas changes can influence genioglossus (GG) activity, we compared GG activity between OSA patients and control subjects during REM sleep using continuous positive airway pressure (CPAP) to minimize the influences of upper-airway resistance (RUA) and blood gas disturbances on GG activity. METHODS: Twenty subjects (10 female subjects), 12 healthy individuals, and 8 OSA patients, were studied overnight. Sleep staging, epiglottic..

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Grants

Awarded by National Institutes of Health


Awarded by American Heart Association


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Awarded by NATIONAL INSTITUTE ON AGING


Funding Acknowledgements

This study was supported by National Institutes of Health grants P50 HL60292, R01 HL085188-01, R01-HL73146, AG024837-01, and RR01032; and by American Heart Association grants 0635318N and 0840159N. Dr. Eckert is supported by the Thoracic Society of Australia and New Zealand/Allen and Han- bury's Respiratory Research Fellowship.