Journal article

Pentobarbital Dose-dependently increases Respiratory Genioglossus Muscle Activity while Impairing Diaphragmatic Function in Anesthetized Rats

Matthias Eikermann, Philipp Fassbender, Sebastian Zaremba, Amy S Jordan, Carl Rosow, Atul Malhotra, Nancy L Chamberlin

ANESTHESIOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2009

Abstract

BACKGROUND: Anesthetics depress both ventilatory and upper airway dilator muscle activity and thus put the upper airway at risk for collapse. However, these effects are agent-dependent and may involve upper airway and diaphragm muscles to varying degrees. The authors assessed the effects of pentobarbital on upper airway dilator and respiratory pump muscle function in rats and compared these results with the effects of normal sleep. METHODS: Tracheostomized rats were given increasing doses of pentobarbital to produce deep sedation then light and deep anesthesia, and negative pressure airway stimuli were applied (n = 11). To compare the effects of pentobarbital with those of natural sleep, the..

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Grants

Awarded by National Institute of Health (Bethesda, Maryland)


Awarded by German Research Council (Bonn, Germany)


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Awarded by NATIONAL INSTITUTE ON AGING


Funding Acknowledgements

Received front the Department of Anesthesia and Critical Care, Massachusetts General Hospital, and Harvard Medical School, Boston, Massuchusetts. Submitted for publication October 21, 2008. Accepted for publication February 4, 2009. Supported by grants P50 HL060292, RO1-HL73146, R01-HL085188, and AG024837 front the National Institute of Health (Bethesda, Maryland), by an Established investigator Award front the American Heart Association (Dallas, Texas), and by grant DFG-EI684/2-1 from the German Research Council (Bonn, Germany).