Hematopoietic defects in the Ts1Cje mouse model of Down syndrome
Catherine L Carmichael, Ian J Majewski, Warren S Alexander, Donald Metcalf, Douglas J Hilton, Chelsee A Hewitt, Hamish S Scott
BLOOD | AMER SOC HEMATOLOGY | Published : 2009
Down syndrome (DS) persons are born with various hematopoietic abnormalities, ranging from relatively benign, such as neutrophilia and macrocytosis, to a more severe transient myeloproliferative disorder (TMD). In most cases, these abnormalities resolve in the first few months to years of life. However, sometimes the TMD represents a premalignant disease that develops into acute megakaryocytic leukemia (AMKL), usually in association with acquired GATA1 mutations. To gain insight into the mechanisms responsible for these abnormalities, we analyzed the hematopoietic development of the Ts1Cje mouse model of DS. Our analyses identified defects in mature blood cells, including macrocytosis and an..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by grants from the APEX Foundation for Research into Intellectual Disability (Sydney, Australia), the National Health and Medical Research Council of Australia (Canberra ACT, Australia; program grants 461219 [W.S.A.], 257501 [H.S.S.], and 219176 [H.S.S.], fellowships 305503[W.S.A.], 461300 [D.J.H.], 171601 [H.S.S.], and 461204 [H.S.S.], a Dora Lush Postgraduate Award [C.L.C.]), the Leukaemia Foundation of Australia (Victoria, Australia; postdoctoral fellowship; C.L.C.), the Australian Government (Canberra, Australia; Australian Postgraduate Award; I.J.M.), the Cancer Council of Australia (Sydney, Australia; postdoctoral fellowship; I.J.M.), the Cancer Council of Victoria (Victoria, Australia; D.M.), the Australian Cancer Research Foundation (Sydney, Australia), and MuriGen Pty Ltd (Victoria, Australia).