Journal article

Late Onset Neutropenia With Clozapine

A Thompson, Boregowda Girishchandra, D Castle, Kenneth Orr

CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE | CANADIAN PSYCHIATRIC ASSOC | Published : 2004

Abstract

Results:The initiation of Leponex in combination with sodium valproate and sertraline resulted in a significant clinical response. In December 1999, monthly FBP revealed mild neutropenia (1.86 x 109/L), with both normal WCC (4.53 x 109/L) and other white cell indices. The neutrophil count increased to 2.22 x 109/L 2 days later and remained above 2 x 109/L. There were 3 further episodes when the patient's neutrophil count dropped below 2 x 109/L with normal WCCs and other FBP parameters, all of which resolved spontaneously. In July 2001, his Leponex dosage was reduced to 250 mg daily following a further transient drop in his neutrophil count. Morning and afternoon testing yielded similarly lo..

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University of Melbourne Researchers