Journal article
The Interleukin-6 Family Cytokine Interleukin-11 Regulates Homeostatic Epithelial Cell Turnover and Promotes Gastric Tumor Development
M Howlett, AS Giraud, H Lescesen, CB Jackson, A Kalantzis, IR Van Driel, L Robb, M Van der Hoek, M Ernst, T Minamoto, A Boussioutas, H Oshima, M Oshima, LM Judd
Gastroenterology | W B SAUNDERS CO-ELSEVIER INC | Published : 2009
Abstract
Background & Aims: Gastric cancer is the second most common cause of cancer-related mortality worldwide, mainly as a result of late-stage detection. Interleukin (IL)-11 is a multifunctional cytokine reported to be up-regulated in human gastric cancer. Methods: We investigated the importance of IL-11 in gastric cancer progression by examining its role in a variety of mouse gastric tumor models, as well as in nonneoplastic and tumor tissues taken from gastric cancer patients. We then determined the transcriptional and translational outcomes of IL-11 overexpression in normal gastric mucosa and identified a novel gene signature important early in the progression toward gastric tumorigenesis. Res..
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